Usually, I like to write a blog about traveling and architecture across the world. But I could not leave the subject go about the Coronavirus, because of the effects and the importance of the world.
Why would you read this article ?
It has interesting articles collected in chronology from different open sources for a broad in-depth view to get your vision.
The possible origins of 2019-nCoV coronavirus
In the early beginning of 26 January, I was in Aruba and studying the news and the development and the reproduction rate of this virus in China. It was growing so fast and vigorously that it had my attention. After a month, it came into Europe spreading via Italie, and then I knew this is not the regular flu and that there is more going on.
The 2019-nCoV has caused a pandemic and more than thousands of laboratory-confirmed infections in humans and thousands of deaths worldwide, some places more than 900 deaths a day.
Two descriptions of the virus published in Nature indicated that the genome sequences from patients were almost identical to the Bat CoV ZC45 coronavirus, and this had my attention. It is critical to study where the pathogen came from and how it passed onto a human.
An article published on The Lancet reported that 27 of 41 infected patients were found to have contact with the Huanan Seafood Market in Wuhan.
People noticed two laboratories researching the bat coronavirus in Wuhan, one of which was only 280 meters from the seafood market. Some people briefly examined the histories of the laboratories and proposed that the Coronavirus probably originated from a laboratory.
Some proposals provided an alternative origin of the Coronavirus in addition to natural recombination and the intermediate host.
And then, I started collecting the Open Source Information and the articles, which in my view, was interesting to read and also the scientific articles.
Governments explained to was your hands and if your sick stay home. But people infected with the novel Coronavirus shed large quantities of the virus early in their illness and likely become less infectious as the disease wears on, according to different studies. That means people who were contagious without symptoms, could be spreading the virus; governments were not proactive and underestimated the effects of this virus, and people working in the field were not adequately equipped.
That means that even when people not had symptoms and was infected with the virus, the virus starts multiplying itself in the body, and the person becomes highly contagious. This is the reason why this virus spreads so fast and so disastrous.
There are still many viruses unknown that hide deep in the forest of the Amazone, waiting for there the first encounter with a human. Most of them only will cause a little flue, but some can be more vicious. For that reason, we have to respect Nature, everyday forests are being cut down, and people are disturbing Nature. The loss of an ecological forest will have consequences, and it will have a loss in the diversity of life there, the outbreak of new viruses can affect the world.
For that reason, we have to respect Nature. Tropical deforestation is not just a problem in Amazonia; we are all connected. The smallest life form -a virus- give us the proof that we all are connected.
Every day there is research done, and new information comes available. I will try to collect scientific articles and archive them on Archive.today because I saw that some sources were changing what they posted before, and I could not find it back anymore. So I put them in a chronological oversight for the one who is interested in reading it.
And of course, if you have an interesting article for me, please send it forward, and you can follow me on social media or keep updated via the newsletter.
The best chronological oversight of the Coronavirus
A Hong Kong team had reported that wildlife traders in Guangdong first caught the SARS coronavirus from civets, mongooses like mammals that are native to tropical and subtropical Asia and Africa.
7-2-2004 SARS Crisis Topples China Lab Chief
“I was hoping for a full, more open account of what happened,” says Tony Della-Porta, an Australian biosafety consultant
4-30-2004 Mounting Lab Accidents Raise SARS Fears
Science 30 Apr 2004: Vol. 304, Issue 5671, pp. 659-661 DOI: 10.1126/science.304.5671.659
Severe acute respiratory syndrome (SARS) emerged in 2002 to 2003 in southern China. The origin of its etiological agent, the SARS coronavirus (SARS-CoV), remains elusive. Here we report that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS outbreak. These viruses, termed SARS-like coronaviruses (SL-CoVs), display greater genetic variation than SARS-CoV isolated from humans or from civets. The human and civet isolates of SARS-CoV nestle phylogenetically within the spectrum of SL-CoVs, indicating that the virus responsible for the SARS outbreak was a member of this coronavirus group.
(…) Source info: In this study, we investigated the receptor usage of the SL-CoV S by combining a human immunodeficiency virus-based pseudovirus system with cell lines expressing the ACE2 molecules of humans, civet, or horseshoe bat.
7-2-2014 FERRETS ARE NOT HUMANS
Government to cease funding gain-of-function studies that make viruses more dangerous, pending a safety assessment.
In the version of this article initially published online, the authors omitted to acknowledge a funding source, USAID-EPT-PREDICT funding from EcoHealth Alliance, to Z.-L.S. The error has been corrected for the print, PDF and HTML versions of this article.
interestingly enough, the Wuhan Institute of Virology was directly involved in its engineering.
“The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently use multiple orthologs of the SARS receptor human angiotensin-converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV.”
Scientists largely agree it came from animals. But that is not the same as saying it didn’t come from the lab;
(…) An experiment that created a hybrid version of a bat coronavirus — one related to the virus that causes SARS (severe acute respiratory syndrome) — has triggered a renewed debate over whether engineering lab variants of viruses with possible pandemic potential is worth the risks.
In an article published in Nature Medicine1 on 9 November, scientists investigated a virus called SHC014, which is found in horseshoe bats in China. The researchers created a chimeric virus, made up of a surface protein of SHC014, and the backbone of a SARS virus that had been adapted to grow in mice and to mimic human disease. The chimera infected human airway cells — proving that the surface protein of SHC014 has the necessary structure to bind to a key receptor on the cells and to infect them. It also caused disease in mice but did not kill them.
Although almost all coronaviruses isolated from bats have not been able to bind to the key human receptor, SHC014 is not the first that can do so. In 2013, researchers reported this ability for the first time in a different coronavirus isolated from the same bat population2.
(…)The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome (MERS)-CoV underscores the threat of cross-species transmission events leading to outbreaks in humans. Here we examine the disease potential of a SARS-like virus, SHC014-CoV, which is currently circulating in Chinese horseshoe bat populations. Using the SARS-CoV reverse genetics system, we generated and characterized a chimeric virus expressing the spike of bat coronavirus SHC014 in a mouse-adapted SARS-CoV backbone. The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently use multiple orthologs of the SARS receptor human angiotensin-converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV.
Accidents in Bio Laboratory
In November 2017, just before the U.S. officials’ visit, Shi’s team had published research showing that horseshoe bats they had collected from a cave in Yunnan province were very likely from the same bat population that spawned the SARS coronavirus in 2003.
In this 30-11-2017 study, Dr. Shi went to Yunan and took blood samples from 218 villagers after testing, she discovered that in nearby caves that the villagers were infected with the bat viruses and that there was a high potential that humans can be infected when they come in contact with bats after she tested the 218 villagers, there were six people infected. And then Dr. Shi went back to study this for a long period of time.
On 18 November 2019, Dr. Shi asked on an online university webpage to ask more students to study the subject.
On the 24th December 2019, she posted that they made a huge discovery in human transmissibility and that they need more help to deal with.
And then it happened to get spooky …
Huan Yeng Ling was a researcher working in the lab on the virology of bats with Dr. Shi and she is missing. Most people believe she is patient zero and most people believe she is dead.
Huan Yeng Ling University profile has completely vanished.
Authorities on alert ahead of lunar new year holiday as 139 new cases of strain detected
On Jan. 9, things got worse. Despair rose when the Wuhan Municipal Health Commission officially announced the death of a 61-year-old man from this new virus. He was the first victim of something that didn’t even have a name. And the Chinese government kept its silence. ( the link is gone I could not find it anymore )
24-1-2020 Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Archive
1-26-202 Coronavirus may have originated in lab linked to China’s biowarfare program Link is gone
1-22-2020 Progress continues in coronavirus trace
Dr. Francis Boyle discusses the coronavirus outbreak in Wuhan, China, and the Biosafety Level 4 laboratory (BSL-4) from which he believes the infectious disease escaped. He believes the virus is potentially lethal and an offensive biological warfare weapon or dual-use biowarfare weapons agent genetically modified with a gain of function properties, which is why the Chinese
A virus that originated in Wuhan, China, has sickened thousands in the country and spread to numerous other nations
This map displays major Biosafety Level 4 (BSL-4) facilities around the world according to data collected by FAS in 2010 and 2011. These high-containment facilities are used to conduct beneficial research on dangerous and emerging pathogens.
This story is no longer available on the site Washington Post, but we made a back up for the real researchers :
The shocking secret behind Wuhan pneumonia
President Xi Jinping warned the public on the seventh day, Jan. 20, but by that time more than 3,000 people had been infected, according to internal documents obtained by The Associated Press and expert estimates based on retrospective infection data.
Instead of creating immunity the virus can reportedly reinfect an individual and hasten fatal heart attack
A Maximum-security bio lab is part of a plan to build a network of BSL-4 facilities across China.
2-22-2020 Inside China’s pathogen lab
2-27-2020 Italiaanse viroloog walgt van paniekzaaierij rondom coronavirus: ‘We zijn niét in oorlog’2-27-2020 Italian virologist is disgusted with panic about coronavirus: “We are not at war.”
This misinformation reached our country and has affected that people did not take things seriously, but:
Four weeks later: 110.574 confirmed cases in Italie, 13.155 deaths in Italie.
Wuhan-based virologist Shi Zhengli has identified dozens of deadly SARS-like viruses in bat caves, and she warns there are more out there
3-13-2020 It was not until March 13 when Trump declared a national emergency and mobilized the vast resources of the federal government to help public-health agencies deal with the crisis that was poised to crash on to the homeland.
Het RIVM heeft als eerste boodschap dat zij bij besmettingen door contactonderzoek de verspreiding kunnen indammen. Men hoeft zich geen zorgen te maken, omdat alleen ouderen en mensen met onderliggende ziekten kwetsbaar zijn, en een besmet persoon kan anderen pas aansteken als hij/zij ziekteverschijnselen vertoont…
De grootste onzin! De dagen ervoor is men also super besmettelijk , niet alleen bij ziekteverschijnselen
3-17-2020 The proximal origin of SARS-CoV-2
They quit the account either personally, by government, of by death.
Police in December had reprimanded eight doctors including Li for warning friends on social media about the emerging threat. China’s supreme court later criticized the police, but the ruling party continued to tighten its grip on information about the outbreak.
The party has faced similar accusations of bungling or thuggish behavior following previous disasters. They include the 2003 outbreak of Severe Acute Respiratory Syndrome, a 2005 chemical spill that disrupted water supplies to millions of people in China’s northeast, sales of tainted milk that sickened thousands of children and the failure of private finance companies after the global economic crisis.
In each case, officials were accused of trying to conceal or delay information people said they needed to protect themselves. Source AP
Research into dangerous viruses and bacteria is important, but for the deadliest pathogens, it’s not clear the benefits are worth the risks.
And I must say: the comments that people leave are more interesting to read.
new studies highlight virus shedding and before-symptom transmission archive
Vanwege de coronauitbraak ligt bijna de helft van de reguliere zorg stil. Er ontstaat een stuwmeer van uitgestelde behandelingen die later moeten worden ingehaald. Dat leidt tot oplopende wachtlijsten en kan zelfs levens kosten, waarschuwen onderzoekers en zelfstandige klinieken. Bron Financiele Dagblad
A leading oncologist has said “the highest priority” sufferers may “not be able to get treatment and this is a tragedy”.
Potential ‘chronic patients’ may have prolonged ability to infect their surroundings, Chinese researchers warn
‘The virus and the host may even form a symbiotic relationship,’ they say Archive.today
Symbiotic Relationships. Symbiosis is a close relationship between two species in which at least one species benefits. For the other species, the relationship may be positive, negative, or neutral. There are three basic types of symbiosis: mutualism, commensalism, and parasitism. Source Wikipedia.
Rapid Expert Consultation on the Possibility of Bioaerosol Spread of SARS-CoV-2 for the COVID-19 Pandemic | Rapid Expert Consultation on the Possibility of Bioaerosol Spread of SARS-CoV-2 for the COVID-19 Pandemic (April 1, 2020) | The National Academies Press
When conducting contact tracing as a COVID-19 containment measure, public health officials should include people with whom the infected person had contact before that person had symptoms, according to a study published yesterday in Morbidity and Mortality Weekly Report.
4-2-2020 Medicijnmacht China tijdens de Corona crisis VIDEO
Yesterday the Food and Drug Administration said the antimalarial drugs hydroxychloroquine and chloroquine are in shortage because of increased pandemic interest in them.
“This letter responds to your question concerning the possibility that [coronavirus] could be spread by conversation, in addition to sneeze/cough-induced droplets,” the letter states. “Currently available research supports the possibility that [coronavirus] could be spread via bioaerosols generated directly by patients’ exhalation,” it continues.
The Netherlands has tried to adopt an “intelligent lockdown,” but the infection is spreading rapidly, and it has one of the world’s highest mortality rates from the pandemic.
(…) Allowing a deadly virus to spread through society to create a level of immunity implicitly means accepting people will die.
Interesting documentary, the files above in one video
“Analysts concluded it could be a cataclysmic event,” a source said.
“When responding to a public health crisis or any other serious security threat, it is critical that our leaders react quickly and take steps to address the threat identified in the intelligence reporting,” said Cohen, the former acting undersecretary of DHS. “It’s not surprising to me that the intelligence community detected the outbreak; what is surprising and disappointing is that the White House ignored the clear warning signs, failed to follow established pandemic response protocols and were slow to put in place a government-wide effort to respond to this crisis.”
The sources believe the initial transmission of the virus – a naturally occurring strain that was being studied there – was bat-to-human and that “patient zero” worked at the laboratory, then went into the population in Wuhan.
The “increasing confidence” comes from classified and open-source documents and evidence, the sources said.
“It is not supposed to be made public — it is an internal document,” said the person, who refused to reveal his name.
In dit tempo duurt het volgens voorzitter Ernst Kuipers van het Landelijk Netwerk Acute Zorg nog zes tot acht weken tot het aantal patiënten op IC”s weer op het “normale niveau” ligt, waardoor uiteindelijk alle andere operaties weer kunnen worden opgestart. Diederik Gommers zei eerder namens de IC-artsen dat het daarvoor nodig is om terug te zakken naar 700 coronabedden.
4-18-2020 US intelligence has ALREADY started a full-scale investigation into Wuhan lab and its ‘role in the virus’ as the White House weighs up what punishment will be dished out to Beijing over ‘coverup Archive
“Our intelligence gaps in China are large enough to drive a truck through, especially when it involves the biggest challenge in intel collection: elite politics,” noted Isaac Stone Fish, a senior fellow at the Asia Society who is writing a book on Beijing’s influence in America. “What’s the relationship between Chairman Xi (Jinping) and the men who run the Central Military Commission, the body that oversees the Party’s military? How much control does Xi have over the Politburo Standing Committee, whose seven members, Xi included, run China? We know astonishingly little about the personalities and power politics at the top of the Party, and I assume that the intel community faces similar limitations.”
Branchini said that because the main source of infections was now within families, the only way to reduce deaths and cases further was to put all people who tested positive in dedicated centers away from their relatives
An interesting documentary to watch on video :
Johns Hopkins experts in global public health, infectious disease, and emergency preparedness have been at the forefront of the international response to COVID-19. This website is a resource to help advance the understanding of the virus, inform the public, and brief policymakers in order to guide response, improve care, and save lives.
More information is posted daily on here to be updated or sign up for the newsletter.
Read more on the link.